| CAS NO: | 362-06-1 |
| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 362-06-1 |
| 别名 | 2-羟雌甾酮,Catecholestrone |
| Canonical SMILES | C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(O)=C(O)C=C4CC3 |
| 分子式 | C18H22O3 |
| 分子量 | 286.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.33 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2-hydroxy Estrone is an active metabolite of the endogenous estrogen estrone .1It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1A2, CYP1A1, and CYP1B1 and metabolized to 2-methoxy estrone by catechol-O-methyltransferase (COMT). 2-hydroxy Estrone (10 µM) inhibits the proliferation of estrogen receptor-positive MCF-7, but not estrogen receptor-negative MDA-MB-231, breast cancer cells cultured with the COMT inhibitor quinalizarin.2It inhibits iron-ADP-adriamycin complex-induced lipid peroxidation of liposomes prepared from rat liver microsomes (IC50= 2.7 µM).3 1.Cribb, A.E., Knight, M.J., Dryer, D., et al.Role of polymorphic human cytochrome P450 enzymes in estrone oxidationCancer Epidemiol. Biomarkers Prev.15(3)551-558(2006) 2.Schneider, J., Huh, M.M., Bradlow, H.L., et al.Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cellsJ. Biol. Chem.259(8)4840-4845(1984) 3.Nakano, M., Sugioka, K., Naito, I., et al.Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-Hydroxy estrone and 2-hydroxy estradiolBiochem. Biophys. Res. Commun.142(3)919-924(1987) |
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