CAS NO: | 1356019-94-7 |
包装: | 1mg |
市场价: | 7182元 |
Cas No. | 1356019-94-7 |
Canonical SMILES | O=C1C2=C(NC[C@H](CNC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)N2[13C]([2H])([2H])[2H])NC(N)=N1 |
分子式 | C19[13C]H22D3N7O6 |
分子量 | 463.5 |
溶解度 | aqueous base: slightly soluble,DMSO: slightly, heated |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Levomefolate-13C-d3is intended for use as an internal standard for the quantification of levomefolate by GC- or LC-MS. Levomefolate is the single (S) isomer of 5-methyltetrahydrofolic acid and an endogenous active form of folic acid .1It donates a methyl group to homocysteine in the biosynthesis of methionine.2Levomefolate (2 mg/kg) prevents decreases in circulating polymorphonucleates induced by methotrexate in an L1210 murine skin lymphocytic leukemia model, and it increases survival in the same model when administered in combination with methotrexate.3Formulations containing levomefolate have been used as dietary supplements, as well as in oral contraceptives for the prevention of neural tube defects in unintended pregnancies. 1.Wang, X., Shen, F., Freisheim, J.H., et al.Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolatesBiochem. Pharmacol.44(9)1898-1901(1992) 2.Ragsdale, S.W.Catalysis of methyl group transfers involving tetrahydrofolate and B12Vitam. Horm.79293-324(2008) 3.Simile, M.M., DeMiglio, M.R., Nufris, A., et al.l-5-formyltetrahydrofolate and l-5-methyltetrahydrofolate rescue in L1210 leukemia treated with high methotrexate dosesRes. Commun. Chem. Pathol. Pharmacol.81(2)251-254(1993) |