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LTX-315(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LTX-315(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A synthetic cationic amphiphilic peptide
Canonical SMILESO=C([C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@@H](NC([C@@H](NC([C@H](CC5=CNC6=CC=CC=C65)NC([C@H](CC7=CNC8=CC=CC=C78)NC([C@@H](NC([C@H](CCCCN)N)=O)CCCCN)=O)=O)=O)CCCCN)=O)CCCCN)=O)=O)N[C@@H](CCCCN)C(N)=O.OC(C(F)(F)F)=O
分子式C78H106N18O9·XCF3COOH
分子量1439.8
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LTX-315 is a synthetic cationic amphiphilic peptide.1It is cytotoxic to a variety of human cancer cell lines, including A20 lymphoma and AT-84 squamous cell carcinoma cells (IC50s = 8.3 and 11 µM, respectively), and to non-cancerous MRC-5 fibroblasts (IC50= 34.3 µM) but not human red blood cells (EC50= >695 µM).2LTX-315 is also cytotoxic to drug-sensitive and -resistant cancer cell lines (IC50s = 2.1-6.4 and 2.5-3.2 µM, respectively). It permeabilizes mitochondrial membranes and induces immunogenic cell death in tumor cellsin vitro.3,1Intratumoral administration of LTX-315 (1 mg peptide/50 µl saline) increases tumor levels of IL-1β and IL-6 and induces necrosis in, and complete regression of, tumors in a B16/F1 syngeneic mouse model of melanoma.4

1.Zhou, H., Forveille, S., Sauvat, A., et al.The oncolytic peptide LTX-315 triggers immunogenic cell deathCell Death Dis.7(3)e2134(2016) 2.Huag, B.E., Camilo, K.A., Eliassen, L.T., et al.Discovery of a 9-mer cationic peptide (LTX-315) as a potential first in class oncolytic peptideJ. Med. Chem.59(7)2918-2927(2016) 3.Zhou, H., Forveille, S., Sauvat, A., et al.The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilizationOncotarget6(29)26599-26614(2015) 4.Camilo, K.A., Berge, G., Ravuri, C.S., et al.Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315Cancer Immunol. Immunother.63(6)601-613(2014)