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4-hydroxy Estrone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-hydroxy Estrone图片
CAS NO:3131-23-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
4-羟基雌酮 (4-OHE1) 是一种雌酮代谢物,对氧化神经毒性具有很强的神经保护作用。
Cas No.3131-23-5
别名4-羟基雌酮; 4-OHE1
Canonical SMILESC[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3
分子式C18H22O3
分子量286.4
溶解度DMSO: slightly soluble,Ethanol: slightly, sonicated
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone .1It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocation of phosphorylated p53 and is protective against glutamate-induced oxidative death in HT22 hippocampal neuronal cells.2It reduces neurodegeneration induced by kainic acid in the rat hippocampus and improves working memory in the Y-maze in rats when administered at a dose of 10 µg/animal. 4-hydroxy Estrone also inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50values of 30 and 38 µM, respectively.3

1.Cribb, A.E., Knight, M.J., Dryer, D., et al.Role of polymorphic human cytochrome P450 enzymes in estrone oxidationCancer Epidemiol. Biomarkers Prev.15(3)551-558(2006) 2.Choi, H.J., Lee, A.J., Kang, K.S., et al.4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damageSci. Rep.10(1)7283(2020) 3.Seeger, H., Huober, J., Wallwiener, D., et al.Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifenHorm. Metab. Res.36(5)277-280(2004)