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Avrainvillamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Avrainvillamide图片
CAS NO:269741-97-1
包装与价格:
包装价格(元)
250µg电议
1mg电议

产品介绍
Avrainvillamide ((+)-Avrainvillamide) 是一种具有抗增殖作用的天然生物碱,与核伴侣核磷蛋白结合,这是一种在许多不同人类肿瘤中过度表达的致癌蛋白。
Cas No.269741-97-1
别名(+)-Avrainvillamide; CJ-17,665
Canonical SMILESO=C1[C@@](C=C(C2=CC=C3C(C=CC(C)(C)O3)=C24)C5=[N]4=O)(NC6=O)[C@@](C5(C)C)([H])CC76N1CCC7
分子式C26H27N3O4
分子量445.5
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Avrainvillamide is a fungal metabolite and monomeric form of stephacidin B that has been found inA. ochraceus.1,2It is active againstS. aureus,S. pyogenes, andE. faecalis(MICs = 12.5, 12.5, and 25 µg/ml, respectively).2Avrainvillamide inhibits the growth of LNCaP, BT-549, T47D, and MALME-3M cancer cells with GI50values of 0.24, 0.62, 0.21, and 0.41 µM, respectively.1

1.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 2.Sugie, Y., Hirai, H., Inagaki, T., et al.A new antibiotic CJ-17,665 from Aspergillus ochraceusJ. Antibiot.54(11)911-916(2001)