| CAS NO: | 136587-07-0 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 136587-07-0 |
| Canonical SMILES | C[C@]1([C@]2([C@]([C@@]3([C@@](C(C)(C(CC3)=O)C)([H])CC2)C)([H])CC4)C)[C@@]4([H])[C@]([C@@H](CC5)C(C)=C)([H])[C@@]5(COC(C)=O)CC1 |
| 分子式 | C32H50O3 |
| 分子量 | 482.7 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin .1It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50= 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both).23-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50= 13.4 µM).3It is also active againstL. donovaniamastigotes when used at a concentration of 50 µM.1 1.Alakurtti, S., BergstrÖm, P., Sacerdoti-Sierra, N., et al.Anti-leishmanial activity of betulin derivativesJ. Antibiot. (Tokyo)63(3)123-126(2010) 2.Pettit, G.R., Melody, N., Hempenstall, F., et al.Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimerJ. Nat. Prod.77(4)863-872(2014) 3.Callies, O., Bedoya, L.M., BeltrÁn, M., et al.Isolation, structural modification, and HIV inhibition of pentacyclic lupane-type triterpenoids from Cassine xylocarpa and Maytenus cuzcoinaJ. Nat. Prod.78(5)1045-1055(2015) |
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