trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.^1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.²It reduces viability of CaCo-2 adenocarcinoma cells with an IC₅₀value of 28.7 mg/L and reduces production of reactive oxygen species (ROS).³trans-Nerolidol is insecticidal againstA. aegyptilarvae with a 24-hour LC₅₀value of 9 mg/L.⁴

1.Nissen, L., Zatta, A., Stefanini, I., et al.Characterization and antimicrobial activity of essential oils of industrial hemp varieties (Cannabis sativa L.)Fitoterapia81(5)413-419(2010) 2.Skaltsa, H.D., Lazari, D.M., Mavromati, A.S., et al.Composition and antimicrobial activity of the essential oil of Scutellaria albida ssp. albida from GreecePlanta Med.66(7)672-674(2000) 3.Ambro?, M., BoušovÁ, I., Skarka, A., et al.The influence of sesquiterpenes from Myrica rubra on the antiproliferative and pro-oxidative effects of doxorubicin and its accumulation in cancer cellsMolecules20(8)15343-15358(2015) 4.Chantraine, J.-M., Laurent, D., Ballivian, C., et al.Insecticidal activity of essential oils on Aedes aegypti larvaePhytother. Res.12(5)350-354(1998)