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Bicalutamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bicalutamide-d4图片
CAS NO:1185035-71-5
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
比卡鲁胺-d4 是氘标记的比卡鲁胺。比卡鲁胺是一种口服活性的非甾体雄激素受体 (AR) 拮抗剂。比卡鲁胺可用于前列腺癌的研究。
Cas No.1185035-71-5
别名比卡鲁胺 d4
Canonical SMILESOC(CS(C1=C([2H])C([2H])=C(F)C([2H])=C1[2H])(=O)=O)(C)C(NC2=CC(C(F)(F)F)=C(C#N)C=C2)=O
分子式C18H10D4F4N2O4S
分子量434.4
溶解度DMSO: Soluble,Methanol: Soluble
储存条件Store at 4°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bicalutamide-d4is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki= 12.5 μM; IC50= 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.1,2Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.3,4

1.Freeman, S.N., Mainwaring, W.I.P., and Furr, B.J.A.A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)Br. J. Cancer60(5)664-668(1989) 2.Masiello, D., Cheng, S., Bubley, G.J., et al.Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptorThe Journal of Biological Chemisty277(29)26321-26326(2002) 3.Gao, W., Kim, J., and Dalton, J.T.Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligandsPharmaceutical Research23(8)1641-1658(2006) 4.Yin, D., Perera, M.A., Dalton, J.T., et al.Key structural features of nonsteroidal ligands for binding and activation of the androgen receptorMolecular Pharmacology63(1)211-223(2003)