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Anastrozole-d12
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anastrozole-d12图片
CAS NO:120512-32-5
包装:1mg
市场价:2646元

产品介绍
Anastrozole-d12 (ZD1033-d12) 是氘标记的 Anastrozole。 Anastrozole 是一种有效的、高度选择性的芳香酶抑制剂,可抑制人胎盘芳香酶,IC50 为 15 nM。
Cas No.120512-32-5
别名ZD1033-d12
Canonical SMILES[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C#N)C1=CC(C(C([2H])([2H])[2H])(C#N)C([2H])([2H])[2H])=CC(CN2C=NC=N2)=C1
分子式C17H7D12N5
分子量305.4
溶解度Chloroform: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Anastrozole-d12is intended for use as an internal standard for the quantification of anastrozole by GC- or LC-MS. Anastrozole is an aromatase/CYP19A1 inhibitor (IC50= 15 nM for human placental aromatase/CYP19A1).1It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats.2It inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys when administered at doses greater than 0.1 mg/kg. Anastrozole (0.5 mg/kg) reduces tumor incidence and the number of tumors by 40 and 57%, respectively, as well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis.3Formulations containing anastrozole have been used in the treatment of breast cancer.

1.Grimm, S.W., and Dyroff, M.C.Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromataseDrug Metabolism and Disposition25(5)598-602(1997) 2.Plourde, P.V., Dyroff, M.C., and Dukes, M.Arimidex®: A potent and selective fourth-generation aromatase inhibitorBreast Cancer Res. Treat.30(1)103-111(1994) 3.Kubatka, P., SadlonovÁ, V., Kajo, K., et al.Chemopreventive effects of anastrozole in a premenopausal breast cancer modelAnticancer Res.28(5A)2819-2823(2008)