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Anagyrine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anagyrine图片
CAS NO:486-89-5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Anagyrine 是一种在 L. albus 中发现的生物碱,具有杀线虫和抗癌活性。它与毒蕈碱和烟碱乙酰胆碱受体 (AChR) 结合,IC50 值分别为 132 和 2096 μM。
Cas No.486-89-5
别名安纳基林,(-)-Anagyrine; Monolupine; Rhombinine
Canonical SMILESO=C1N(C2=CC=C1)C[C@]3([H])[C@@]4([H])CCCCN4C[C@@]2([H])C3
分子式C15H20N2O
分子量244.3
溶解度DMSO: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Anagyrine is an alkaloid that has been found inL. albusand has nematocidal and anticancer activities.1,2,3It binds to muscarinic and nicotinic acetylcholine receptors (AChRs) with IC50values of 132 and 2,096 µM, respectively, in radioligand binding assays using pig brain membranes that endogenously express high levels of the receptors.1Anagyrine decreases survival ofB. xylophilusworms.2It inhibits proliferation of TE-671 and SH-SY5Y cancer cells (EC50s = 18.1 and 19.1 µM, respectively).3Maternal ingestion of anagyrine during gestation is associated with the teratogenic condition crooked calf disease in cattle.4

1.Schmeller, T., Sauerwein, M., Sporer, F., et al.Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptorsJ. Nat. Prod.57(9)1316-1319(1994) 2.Matsuda, K., Kimura, K., Komai, K., et al.Nematicidal activities of (-)-N-methylcytisine and (-)-anagyrine from Sophora flavescens against pine wood nematodesAgr. BioI. Chem.53(8)2287-2288(1989) 3.Green, B.T., Lee, S.T., Panter, K.E., et al.Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptorsNeurotoxicol. Teratol.32(3)383-390(2010) 4.Keeler, R.F., Cronin, E.H., and Shupe, J.L.Lupin alkaloids from teratogenic and nonteratogenic lupins. IV. Concentration of total alkaloids, individual major alkaloids, and the teratogen anagyrine as a function of plant part and stage of growth and their relationship to crooked calf diseaseJ. Toxicol. Environ. Health1(6)899-908(1976)