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11β-Prostaglandin F2α-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
11β-Prostaglandin F2α-d4图片
CAS NO:1240398-18-8
包装与价格：
包装价格(元)
50 μg电议
100 μg电议
500 μg电议

产品介绍
An internal standard for the quantification of 11β-PGF F2α
Cas No.1240398-18-8
Canonical SMILESO[C@@H]1[C@H](/C=C/[C@H](O)CCCCC)[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](O)C1
分子式C20H30D4O5
分子量358.5
溶解度Ethanol: 100 mg/ml,DMF: 100 mg/ml,DMSO: 100 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

11β-Prostaglandin F2α-d4(11β-PGF2α-d4) is intended for use as an internal standard for the quantification of 11β-PGF2αby GC- or LC-MS. 11β-PGF2αis the primary metabolite of PGD2.1It is formed from PGD2viathe NADPH-dependent aldo-keto reductase PGF synthase in the liver or lung.211β-PGF2αinduces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α(FP) receptors, with an EC50value of 0.045 µM.1It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.311β-PGF2α(0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.4

1.Giles, H., Bolofo, M.L., Lydford, S.J., et al.A comparative study of the prostanoid receptor profile of 9α 11 β-prostaglandin F2 and prostaglandin D2Br. J. Pharmacol.104(2)541-549(1991) 2.Watanabe, K.Prostaglandin F synthaseProstaglandins Other Lipid Mediat.68-69401-407(2002) 3.Coleman, R.A., and Sheldrick, R.L.G.Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptorsBr. J. Pharmacol.96(3)688-692(1989) 4.Yoda, T., Kikuchi, K., Miki, Y., et al.11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancerMol. Cell. Endocrinol.413236-247(2015)