| CAS NO: | 1041-01-6 |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1 g | 电议 |
| 5 g | 电议 |
| 10 g | 电议 |
| Cas No. | 1041-01-6 |
| 别名 | 3,5-二碘-L-甲状腺素,3,5-Diiodo-L-thyronine |
| Canonical SMILES | IC(C=C(C=C1I)C[C@H](N)C(O)=O)=C1OC2=CC=C(C=C2)O |
| 分子式 | C15H13I2NO4 |
| 分子量 | 525.1 |
| 溶解度 | DMF: 1 mg/ml,DMSO: insol,Ethanol: insol,PBS (pH 7.2): insol |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite.1It binds to thyroid hormone receptor α1(TRα1), TRβ1, and TRβ2(EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays).23,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism induced by sodium iodide.3It reduces subcutaneous and epididymal fat mass, as well as decreases serum leptin and cholesterol levels, without affecting body weight in high-fat diet-induced obese mice when administered at a dose of 2.5 µg/g per day.1 1.Jonas, W., Lietzow, J., Wohlgemuth, F., et al.3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese miceEndocrinology156(1)389-399(2015) 2.Ball, S.G., Sokolov, J., and Chin, W.W.3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitroJ. Mol. Endocrinol.19(2)137-147(1997) 3.Horst, C., Rokos, H., and Seitz, H.J.Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-?-thyronineBiochem. J.261(3)945-950(1989) |
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