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Isopimaric Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isopimaric Acid图片
CAS NO:5835-26-7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
异海松酸是大电导钙激活 K+ (BK) 通道的有效开启剂。
Cas No.5835-26-7
别名异海松酸
Canonical SMILESC[C@@]12[C@](CC=C3[C@]2([H])CC[C@@](C)(C3)C=C)([H])[C@@](C)(CCC1)C(O)=O
分子式C20H30O2
分子量302.5
溶解度Chloroform: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Isopimaric acid is a diterpenoid resin acid that has been found inP. nigraand has diverse biological activities.1,2,3,4It is active against clinical isolates of epidemic methicillin-resistantS. aureus(EMRSA; MICs = 32-64 µg/ml).1Isopimaric acid is an agonist of retinoid X receptor alpha (RXRα), RXRβ, and RXRγ in a reporter assay using HEK293T cells expressing human receptors (EC50s = 26, 32, and 33 µM, respectively).2It opens large conductance calcium-activated potassium channels (BKCa1.1/KCa1.1) in HEK293 cells expressing recombinant channels and the activating β1 regulatory subunit when used at a concentration of 10 µM.3Isopimaric acid potentiates reductions in field excitatory postsynaptic potential (fEPSP) slopes in hippocampal slices and decreases escape latency in the Morris water maze in a 3xTg mouse model of Alzheimer’s disease.4It has been found as an environmental contaminant in pulp and paper mill effluent.5

1.Smith, E., Williamson, E., Zloh, M., et al.Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureusPhytother. Res.19(6)538-542(2005) 2.Merk, D., Grisoni, F., Friedrich, L., et al.Computer-assisted discovery of retinoid X receptor modulating natural products and isofunctional mimeticsJ. Med. Chem.61(12)5442-5447(2018) 3.Imaizumi, Y., Sakamoto, K., Yamada, A., et al.Molecular basis of pimarane compounds as novel activators of large-conductance Ca2+-activated K+ channel α-subunitMol. Pharmacol.62(4)836-846(2002) 4.Wang, L., Kang, H., Li, Y., et al.Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer’s diseaseNeuropharmacology928-15(2015) 5.van den Heuvel, M.R., Ellis, R.J., Tremblay, L.A., et al.Exposure of reproductively maturing rainbow trout to a New Zealand pulp and paper mill effluentEcotoxicol. Environ. Saf.51(1)65-75(2002)