| CAS NO: | 53-02-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 53-02-1 |
| Canonical SMILES | C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C |
| 分子式 | C21H34O5 |
| 分子量 | 366.5 |
| 溶解度 | Chloroform: 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5β-Tetrahydrocortisol is an endogenous metabolite of hydrocortisone .1,2It is also an intermediate in the biosynthesis of β-cortol .2It is formed from cortisol by steroid 5β-reductase and is dehydrogenated by 20β-hydroxysteroid dehydrogenase (20β-HSD) to produce β-cortol in the liver.3,1,2Urinary levels of 5β-tetrahydrocortisol have been used as a marker for cortisol production and are associated with metabolic syndrome in obese individuals.4 1.Shackleton, C.H.L.Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesisLipids47(1)1-12(2012) 2.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 3.Kosicka, K., Siemi?tkowska, A., Pa?ka, D., et al.Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MSJ. Pharm. Biomed. Anal.140174-181(2017) 4.Baudrand, R., Campino, C., Carvajal, C.A., et al.Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunctionSteroids76(14)1575-1581(2011) |
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