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Deslorelin(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Deslorelin(acetate)图片
CAS NO:1642579-30-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A peptide agonist of GnRH
Cas No.1642579-30-3
Canonical SMILESOC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H]2NC(CC2)=O)=O)CC3=CN=CN3)=O)CC4=CNC5=CC=CC=C45)=O)=O)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(NCC)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O.CC(O)=O
分子式C64H83N17O12·XC2H4O2
分子量1282.5
溶解度DMF: 5 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Deslorelin is a peptide agonist of gonadotropin-releasing hormone (GnRH).1It binds to the GnRH receptor (GnRHR) with a Kivalue of 0.1 nM. Deslorelin decreases testicular volume, semen volume, sperm motility, and total sperm count, as well as increases the percentage of abnormal sperm, in dogs when administeredviaa subcutaneous implant at doses of 3, 6, and 12 mg/kg.2It decreases disease severity and plasma levels of estradiol, 17-hydroxyprogesterone, and androstenedione in ferrets with adrenocortical disease (ACD) when administered at doses ranging from 3 to 4.41 mg/kg per implant.3Deslorelin (4.7 mg/implant per animal) suppresses ovulation and estrus in cats.4Formulations containing deslorelin have been used in the management of ACD in ferrets and ovulation regulation and artificial insemination in horses.

1.Nederpelt, I., Georgi, V., Schiele, F., et al.Characterization of 12 GnRH peptide agonists - a kinetic perspectiveBr. J. Pharmacol.173(1)128-141(2016) 2.Junaidi, A., Williamson, P.E., Martin, G.B., et al.Dose-response studies for pituitary and testicular function in male dogs treated with the GnRH superagonist, deslorelinReprod. Domest. Anim.44(5)725-734(2009) 3.Wagner, R.A., PichÉ, C.A., JÖchle, W., et al.Clinical and endocrine responses to treatment with deslorelin acetate implants in ferrets with adrenocortical diseaseAm. J. Vet. Res.66(5)910-914(2005) 4.Ackermann, C.L., Volpato, R., Destro, F.C., et al.Ovarian activity reversibility after the use of deslorelin acetate as a short-term contraceptive in domestic queensTheriogenology78(4)817-822(2012)