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Tauro-α-muricholic Acid-d4(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tauro-α-muricholic Acid-d4(sodium salt)图片
包装与价格：
包装价格(元)
500 µg电议
1mg电议

产品介绍
An internal standard for the quantification of tauro-α-muricholic acid
Canonical SMILESC[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@@H](O)[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
分子式C26H40D4NO7S·Na
分子量541.7
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tauro-α-muricholic acid-d4(TαMCA-d4) is intended for use as an internal standard for the quantification of TαMCA by GC- or LC-MS. TαMCA is an antagonist of the farnesoid X receptor (FXR; IC50= 28 µM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid .1TαMCA is common in rodents but has also been found in small amounts in human serum.2

1.Sayin, S.I., WahlstrÖm, A., Felin, J., et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistCell Metab.17(2)225-235(2013) 2.GarcÍa-CaÑaveras, J.C., Donato, M.T., Castell, J.V., et al.Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated methodJ. Lipid Res.53(10)2231-2241(2012)