| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Canonical SMILES | CN(C([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(O)=O)=O)CC1=CC=CC=C1)=O)[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)CC2=CC=CC=C2.FC(F)(C(O)=O)F |
| 分子式 | C40H55N7O11S·XCF3COOH |
| 分子量 | 842 |
| 溶解度 | DMSO: 5 mg/ml,PBS (pH 7.2): 2 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50= 0.5-3 nM).1,2,3It less potently agonizes the NK1receptor (EC50= 35 µM) and is without effect on the NK2receptor.1,2,3Senktide is used to study the action of the NK3receptor in cells and in animals.4,5 1.Byk, G., Halle, D., Zeltser, I., et al.Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance PJ. Med. Chem39(16)3174-3178(1996) 2.Sarau, H.M., Griswold, D.E., Potts, W., et al.Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonistJ. Pharmacol. Exp. Ther.281(3)1303-1311(1997) 3.Harrison, T., Korsgaard, M.P., Swain, C.J., et al.High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural templateBioorg. Med. Chem. Lett.8(11)1343-1348(1998) 4.Thakar, A., Sylar, E., and Flynn, F.W.Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylationPeptides38(2)282-290(2012) 5.Gaskins, G.T., Glanowska, K.M., and Moenter, S.M.Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult miceEndocrinology154(11)3984-3989(2013) |
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