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Senktide(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Senktide(trifluoroacetate salt)图片
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
A potent NK3 receptor agonist
Canonical SMILESCN(C([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(O)=O)=O)CC1=CC=CC=C1)=O)[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)CC2=CC=CC=C2.FC(F)(C(O)=O)F
分子式C40H55N7O11S·XCF3COOH
分子量842
溶解度DMSO: 5 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50= 0.5-3 nM).1,2,3It less potently agonizes the NK1receptor (EC50= 35 µM) and is without effect on the NK2receptor.1,2,3Senktide is used to study the action of the NK3receptor in cells and in animals.4,5

1.Byk, G., Halle, D., Zeltser, I., et al.Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance PJ. Med. Chem39(16)3174-3178(1996) 2.Sarau, H.M., Griswold, D.E., Potts, W., et al.Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonistJ. Pharmacol. Exp. Ther.281(3)1303-1311(1997) 3.Harrison, T., Korsgaard, M.P., Swain, C.J., et al.High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural templateBioorg. Med. Chem. Lett.8(11)1343-1348(1998) 4.Thakar, A., Sylar, E., and Flynn, F.W.Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylationPeptides38(2)282-290(2012) 5.Gaskins, G.T., Glanowska, K.M., and Moenter, S.M.Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult miceEndocrinology154(11)3984-3989(2013)