| CAS NO: | 22395-22-8 |
| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Cas No. | 22395-22-8 |
| 别名 | 7-甲氧基黄酮 |
| Canonical SMILES | O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=CC=C13 |
| 分子式 | C16H12O3 |
| 分子量 | 252.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 7-Methoxyflavone is a flavone that has been found inZ. brasiliensisand has diverse biological activities.1,2,3,4It inhibits aromatase (IC50= 1.9 µM in a cell-free assay) and LPS-induced nitric oxide (NO) production by 17.74% in RAW 264.7 macrophages when used at a concentration of 20 µM.1,27-Methoxyflavone activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay and has antinociceptive effects in the acetic acid-induced writhing test in mice (ED50= 82.5 µmol/kg).3,4 1.Ta, N., and Walle, T.Aromatase inhibition by bioavailable methylated flavonesJ. Steroid. Biochem. Mol. Biol.107(1-2)127-129(2007) 2.An, J.-Y., Lee, H.-H., Shin, J.-S., et al.Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cellsBioorg. Med. Chem. Lett.27(11)2613-2616(2017) 3.Nishizaki, Y., Ishimoto, Y., Hotta, Y., et al.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assayBioorg. Med. Chem. Lett.19(16)4706-4710(2009) 4.da Silva, A.D.S., Cavalcante-Silva, L.H.A., da Matta, C.B.B., et al.Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensisNat. Prod. Res.27(18)1695-1699(2013) |
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