| CAS NO: | 2280940-18-1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 2280940-18-1 |
| Canonical SMILES | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@@]4(C(CCl)=O)OC(C([2H])([2H])C([2H])([2H])[2H])=O)=C1 |
| 分子式 | C25H27ClD5FO5 |
| 分子量 | 472 |
| 溶解度 | Methanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Clobetasol propionate-d5is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid.1It binds to glucocorticoid receptors in a cell-free assay (IC50= 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml.1,2Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.1Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions. 1.Ueno, H., Maruyama, A., Miyake, M., et al.Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional groupJ. Med. Chem.34(8)2468-2473(1991) 2.Ponec, M., de Haas, C., Bachra, B.N., et al.Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblastsArch. Dermatol. Res.259(12)117-123(1977) |
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