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CAY10771
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY10771图片
CAS NO:2522599-79-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A dual agonist of FXR and PPARδ
Cas No.2522599-79-5
Canonical SMILESClC1=CC=CC(Cl)=C1C2=NOC(C(C)C)=C2COC3=CC(Cl)=C(CNC4=CC=C(CC(O)=O)C=C4)C=C3
分子式C28H25Cl3N2O4
分子量559.9
溶解度Acetonitrile: 5 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 µM.

1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020)