CAS NO: | 1631754-28-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 1631754-28-3 |
别名 | 卡贝缩宫素醋酸盐 |
Canonical SMILES | O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([C@@H](C)CC)([H])NC1=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CSCCCC(N[C@H]1CC2=CC=C(OC)C=C2)=O)N3[C@H](C(N[C@@H](CC(C)C)C(NCC(N)=O)=O)=O)CCC3.CC(O)=O |
分子式 | C45H69N11O12S•XC2H4O2 |
分子量 | 988.2 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Carbetocin is an oxytocin receptor agonist and a peptide analog of oxytocin .1It selectively binds to oxytocin receptors over vasopressin V2receptors (Kds = 1.96 and 61.3 nM, respectively). Carbetocin induces contraction of isolated rat uterine strips (EC50= 48 nM) and inhibits oxytocin-induced contraction of isolated rat uterine strips (pA2= 8.21).In vivo, carbetocin (0.35 mg/animal) increases the frequency and amplitude of uterine contractions in early postpartum dairy cows.2Carbetocin (6.4 mg/kg, i.p.) prevents stress-induced reinstatement of morphine-seeking behavior in mice.3It also reverses learned helplessness and decreases social withdrawal induced by chronic unpredictable stress in tree shrews.4Formulations containing carbetocin have been used in the prevention of excessive bleeding after childbirth. 1.EngstrØm, T., Barth, T., Melin, P., et al.Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradationEur. J. Pharmacol.355(2-3)203-210(1998) 2.Bajcsy, Á.C., Szenci, O., van der Weijden, G.C., et al.The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cowsTheriogenology65(2)400-414(2006) 3.Zanos, P., Georgiou, P., Wright, S.R., et al.The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent miceNeuropsychopharmacology39(4)855-865(2014) 4.Meng, X., Shen, F., Li, C., et al.Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocinPharmacol. Biochem. Behav.1451-8(2016) |