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Propylthiouracil-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propylthiouracil-d5图片
CAS NO:1189423-94-6
包装:2.5mg
市场价:4309元

产品介绍
An internal standard for the quantification of propylthiouracil
Cas No.1189423-94-6
别名6-n-Propylthiouracil-d5; 6-Propyl-2-thiouracil-d5; PTU-d5
Canonical SMILESO=C1NC(NC(CC([2H])([2H])C([2H])([2H])[2H])=C1)=S
分子式C7H5D5N2OS
分子量175.3
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propylthiouracil-d5is intended for use as an internal standard for the quantification of propylthiouracil by GC- or LC-MS. Propylthiouracil (PTU) is a thioamide antithyroid agent.1It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.2Formulations containing propylthiouracil have been used in the treatment of Graves' disease and hyperthyroidism.

1.Takayama, S., Aihara, K., Onodera, T., et al.Antithyroid effects of propylthiourad and sulfamonomethoxine in rats and monkeysToxicol. Appl. Pharmacol.82(2)191-199(1986) 2.Drewnowski, A., and Rock, C.L.The influence of genetic taste markers on food acceptanceAm. J. Clin. Nutr.62(3)506-511(1995)