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Pexiganan(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:172820-23-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An antimicrobial peptide
Cas No.172820-23-4
别名培西加南
Canonical SMILES[H]NCCCC[C@H](NC(CNC([C@](NC(CN[H])=O)([H])[C@H](CC)C)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@H](C(NCC(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N)=O)=O)=O)CC(C)C)=O)([H])[C@H](CC)C)=O)=O)=O)CC1=CC=CC=C1)=O)C)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC3=CC=CC=C3)=O.CC(O)=O
分子式C122H210N32O22 ? XC2H4O2
分子量2477.2
溶解度DMF: Slightly soluble,DMSO: Slightly soluble,Ethanol: 12 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pexiganan is a synthetic antimicrobial peptide.1It is active against various clinical isolates of bacteria from patients with diabetic foot infections, includingS. aureus, methicillin-resistantS. aureus(MRSA), andP. aeruginosa(MICs = 16-32, 16-32, and 8-16 µg/ml, respectively). Pexiganan (1 mg/kg) decreases lethality in a mouse model of sepsis induced byA. baumannii.2

1.Flamm, R.K., Rhomberg, P.R., Simpson, K.M., et al.In vitro spectrum of pexiganan activity when tested against pathogens from diabetic foot infections and with selected resistance mechanismsAntimicrob. Agents Chemother.59(3)1751-1754(2015) 2.Cirioni, O., Simonetti, O., Pierpaoli, E., et al.Enhanced efficacy of combinations of pexiganan with colistin versus Acinetobacter Baumannii in experimental sepsisShock46(2)219-225(2016)