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Lys-(Des-Arg9,Leu8)-Bradykinin(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A bradykinin B1receptor antagonist
Canonical SMILESN[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N1[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@@H](CO)C(N3[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC3)=O)=O)CC4=CC=CC=C4)=O)=O)CCC2)=O)CCC1)=O)=O.OC(C(F)(F)F)=O
分子式C47H75N13O11 • XCF3COOH
分子量998.2
溶解度DMF: 1 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lys-(Des-Arg9, Leu8)-Bradykinin is a bradykinin B1receptor antagonist (Ki= 0.43 nM for the rabbit aorta receptor).1It is selective for the bradykinin B1over the B2receptor (Ki= >10 µM for the rabbit ileum receptor).2Lys-(Des-Arg9, Leu8)-Bradykinin inhibits contractions induced by the bradykinin B1receptor agonist Des-Arg9-bradykinin in isolated rabbit aortic rings (pA2= 8.54).3Intraperitoneal administration of Lys-(Des-Arg9, Leu8)-bradykinin (5 mg/kg per day for three days) reduces increases in paw edema in a rat model of arthritis induced by peptidoglycan-polysaccharide (PGPS).4

1.MacNeil, T., Bierilo, K.K., Menke, J.G., et al.Cloning and pharmacological characterization of a rabbit bradykinin B1 receptorBiochim. Biophys. Acta1264(2)223-228(1995) 2.Meini, S., Cucchi, P., Catalani, C., et al.Radioligand binding characterization of the bradykinin B2 receptor in the rabbit and pig ileal smooth muscleEur. J. Pharmacol.635(1-3)34-39(2010) 3.Drapeau, G., Audet, R., Levesque, L., et al.Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kininsJ. Pharmacol. Exp. Ther.266(1)192-199(1993) 4.Blais, C., Jr., Couture, R., Drapeau, G., et al.Involvement of endogenous kinins in the pathogenesis of peptidoglycan-induced arthritis in the Lewis ratArthritis Rheum.40(7)1327-1333(1997)