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γ-D-Glutamylglycine(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
γ-D-Glutamylglycine(trifluoroacetate salt)图片
CAS NO:71822-19-0
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
An excitatory amino acid antagonist
Cas No.71822-19-0
Canonical SMILESOC(CNC(CC[C@@H](N)C(O)=O)=O)=O.FC(F)(C(O)=O)F
分子式C7H12N2O5 • CF3COOH
分子量318.2
溶解度Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA , quisqualate, kainate, and glutamate.1It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 µM, respectively).2γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 µmol, i.c.v., respectively).3

1.Crunelli, S., Forda, S., and Kelly, J.S.Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrusJ. Physiol.341627-640(1983) 2.Raigorodsky, G., and Urca, G.Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartateEur. J. Pharmacol.182(1)37-47(1990) 3.Croucher, M.J., Collins, J.F., and Meldrum, B.S.Anticonvulsant action of excitatory amino acid antagonistsScience216(4548)899-901(1982)