CAS NO: | 71822-19-0 |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
Cas No. | 71822-19-0 |
Canonical SMILES | OC(CNC(CC[C@@H](N)C(O)=O)=O)=O.FC(F)(C(O)=O)F |
分子式 | C7H12N2O5 • CF3COOH |
分子量 | 318.2 |
溶解度 | Water: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA , quisqualate, kainate, and glutamate.1It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 µM, respectively).2γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 µmol, i.c.v., respectively).3 1.Crunelli, S., Forda, S., and Kelly, J.S.Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrusJ. Physiol.341627-640(1983) 2.Raigorodsky, G., and Urca, G.Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartateEur. J. Pharmacol.182(1)37-47(1990) 3.Croucher, M.J., Collins, J.F., and Meldrum, B.S.Anticonvulsant action of excitatory amino acid antagonistsScience216(4548)899-901(1982) |