| CAS NO: | 80943-40-4 |
| 包装: | 100mg |
| 市场价: | 2646元 |
| Cas No. | 80943-40-4 |
| Canonical SMILES | CCCCCCCCCC(N[C@@H]([C@@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl |
| 分子式 | C23H38N2O3• HCl |
| 分子量 | 427 |
| 溶解度 | DMF: 25 mg/mL,DMSO: 30 mg/mL,Ethanol: 50 mg/mL,Ethanol:PBS(pH 7.2) (1:5): 0.05 mg/mL |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.1,2It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 µM.2Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 µM.3It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 µM but is cytotoxic at concentrations higher than 50 µM.4[Matreya, LLC. Catalog No. 1755] 1.Vunnam, R.R., and Radin, N.S.Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brainChem. Phys. Lipids26(3)265-278(1980) 2.Abe, A., Radin, N.S., and Shayman, J.A.Induction of glucosylceramide synthase by synthase inhibitors and ceramideBiochim. Biophys. Acta.1299(3)333-341(1996) 3.Inokuchi, J.i., and Radin, N.S.Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetaseJ. Lipid Res.28(5)565-571(1987) 4.Uemura, K., Sugiyama, E., Tamai, C., et al.Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblastsJ. Biochem.108(4)525-530(1990) |
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