Orexin B amide(human)(trifluoroacetate salt)

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Orexin B amide(human)(trifluoroacetate salt)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Orexin B amide(human)(trifluoroacetate salt)图片

包装:	500 µg
市场价:	4326元

产品介绍

A hypothalamic neuropeptide

Canonical SMILES	NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC(CNC([C@@H]1CCCN1C([C@@H]2CCCN2C(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)N[H])=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC3=CN=CN3)=O)C)=O)C)=O)=O)=O)=O)=O)CCSC)=O.FC(F)(C(O)=O)F
分子式	C₁₂₃H₂₁₂N₄₄O₃₅S • XCF₃COOH
分子量	2899.3
溶解度	Water: 1 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Orexin B amide is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.¹It is an agonist of orexin (OX) receptors with IC₅₀values of 420 and 36 nM for human recombinant OX₁and OX₂receptors, respectively, expressed in CHO cells.²It induces transient increases in intracellular calcium in CHO cells stably expressing OX₁and OX₂(EC₅₀s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons.^2,3Orexin B amide stimulates arachidonic acid release from CHO cells expressing human recombinant OX₁(EC₅₀= 4.17 nM).⁴It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.^2,5 1.Mahler, S.V., Moorman, D.E., Smith, R.J., et al.Motivational activation: A unifying hypothesis of orexin/hypocretin functionNat. Neurosci.17(10)1298-1303(2014) 2.Sakurai, T., Amemiya, A., Ishii, M., et al.Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorCell92(4)573-585(1998) 3.Nakamura, T., Uramura, K., Nambu, T., et al.Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic systemBrain Res.873(1)181-187(2000) 4.Turunen, P.M., Ekholm, M.E., Somerharju, P., et al.Arachidonic acid release mediated by OX1 orexin receptorsBr. J. Pharmacol.159(1)212-221(2010) 5.Volkoff, H., Bjorklund, J.M., and Peter, R.E.Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-BBrain Res.846(2)204-209(1999)