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Lidocaine-d10
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lidocaine-d10图片
CAS NO:851528-09-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of lidocaine
Cas No.851528-09-1
别名利多卡因 d10
Canonical SMILES[2H]C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])[2H])CC(N(C1=C(C)C=CC=C1C)[H])=O
分子式C14H12D10N2O
分子量244.4
溶解度DMSO: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lidocaine-d10is intended for use as an internal standard for the quantification of lidocaine by GC- or LC-MS. Lidocaine is an inhibitor of voltage-gated sodium channels (Navs) and a local anesthetic.1,2,3It inhibits Nav1.2 (Ki= 11 µM), adult and neonatal Nav1.5 (IC50s = 380.1 and 360 µM, respectively), and Nav1.7 and Nav1.8 channels (IC50s = 450 and 104 µM, respectively) expressed inXenopusoocytes. Topical administration of lidocaine (1-2%) reduces escape behavior in a rhesus monkey model of noxious electrical cutaneous pain.4Formulations containing lidocaine have been used as local and regional anesthetics.

1.Ragsdale, D.S., McPhee, J.C., Scheuer, T., et al.Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channelsProc. Natl. Acad. Sci. USA93(17)9270-9275(1996) 2.Fraser, S.P., Onkal, R., Theys, M., et al.Neonatal Nav1.5 channels: Pharmacological distinctiveness of a cancer-related voltage-gated sodium channel splice variantBr. J. Pharmacol.Online ahead of print(2021) 3.Chevrier, P., Vijayaragavan, K., and Chahine, M.Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaineBr. J. Pharmacol.142(3)576-584(2004) 4.Lineberry, C.G., and Kulics, A.T.The effects of diazepam, morphine and lidocaine on nociception in rhesus monkeys: A signal detection analysisJ. Pharmacol. Exp. Ther.205(2)302-310(1978)