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Stobadine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Stobadine图片
CAS NO:85202-17-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A pyridoindole antioxidant
Cas No.85202-17-1
别名2,8-二甲基-2,3,4,4A,5,9B-六氢-1H-吡啶并[4,3-B]吲哚二盐酸盐
Canonical SMILESCC1=CC=C2N[C@@](CCN(C3)C)([H])[C@@]3([H])C2=C1
分子式C13H18N2
分子量202.3
溶解度DMSO: >100mM
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Stobadine is a pyridoindole antioxidant.1It scavenges hydroxyl, peroxyl, and alkoxyl radicals and quenches singlet oxygen in cell-free assays.Ex vivo, stobadine (2 mg/kg) reduces lipid peroxidation induced by hypoxia and reoxygenation in rat forebrain.2It improves survival in a rat model of carotid artery ligation-induced cerebral ischemia. Stobadine (1 mg/kg, i.v.) increases myocardial blood flow and decreases infarct area in a dog model of myocardial infarction induced by acute occlusion of the left coronary artery.1Dietary administration of stobadine (0.05% w/w) delays the development of cataracts and reduces eye lens protein oxidation and plasma levels of malondialdehyde (MDA) in a rat model of diabetes induced by streptozotocin .3

1.HorÁkovÁ, L., and štolc, S.Antioxidant and pharmacodynamic effects of pyridoindole stobadineGen. Pharmacol.30(5)627-638(1998) 2.štolc, S., VlkolinskÝ, R., and PavlÁsek, J.Neuroprotection by the pyridoindole stobadine: A minireviewBrain Res. Bull.42(5)335-340(1997) 3.Kyselova, Z., Gajdosik, A., Gajdosikova, A., et al.Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: Comparison with vitamin E and BHTMol. Vis.1156-65(2005)