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ARA 290(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ARA 290(acetate)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A derivative of EPO
Canonical SMILESOC([C@H](CO)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
分子式C51H84N16O21• XC2H4O2
分子量1257.3
溶解度DMF: insol,DMSO: 5 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ARA 290 is a derivative of erythropoietin (EPO).1In vivo, ARA 290 (0.8 and 8 nmol/kg, i.p.) reduces plasma creatine, urea, and aspartate aminotransferase (AST) levels, markers of renal dysfunction, in a rodent model of renal ischemia-reperfusion injury. It decreases wound area in a rat model of punch biopsy-induced dermal injury and a rat model of decubitus ulcer.2ARA 290 (30 µg/kg, i.p.) reduces the latency to find the platform in the Morris water maze in a rat model of cortical impact-induced traumatic brain injury (TBI).3It also reduces tactile allodynia in a rat model of neuropathic pain induced by spinal nerve injury (SNI).4

1.Brines, M., Patel, N.S.A., Villa, P., et al.Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietinProc. Natl. Acad. Sci. USA105(31)10925-10930(2008) 2.Erbayraktar, Z., Erbayraktar, S., Yilmaz, O., et al.Nonerythropoietic tissue protective compounds are highly effective facilitators of wound healingMol. Med.15(7-8)235-241(2009) 3.Robertson, C.S., Garcia, R., Gaddam, S.S.K., et al.Treatment of mild traumatic brain injury with an erythropoietin-mimetic peptideJ. Neurotrauma30(9)765-774(2013) 4.Swartjes, M., Niesters, M., and Dahan, A.Assessment of allodynia relief by tissue-protective molecules in a rat model of nerve injury-induced neuropathic painMethods Mol. Biol.982187-195(2013)