![Guanosine 5&rsquo-[γ-thio]triphosphate(lithium salt)图片](http://www.cnreagent.com/data/daily/2023/01/06/150806_380727_umcs_1047296.png)
| CAS NO: | 94825-44-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 94825-44-2 |
| 别名 | 鸟苷-5ˊ-O-(3-硫代三磷酸)四锂盐 |
| Canonical SMILES | O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP(O)(S)=O)(O)=O)(O)=O)([H])N2C3=C(C(N=C(N3)N)=O)N=C2.[Li] |
| 分子式 | C10H16N5O13P3S • 4Li |
| 分子量 | 567 |
| 溶解度 | Water: 75 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Guanosine 5’-[γ-thio]triphosphate (GTPγS) is a hydrolysis-resistant analog of GTP that binds to and activates G proteins in the presence of magnesium.1GTPγS has been used to obtain crystal structures of GTPases in their active states, as well as measure the stability of GTPases in the presence of ligands.2,3A radiolabeled form of GTPγS, [35S]GTPγS, is commonly used in binding assays to determine agonism or antagonism at G protein-coupled receptors (GPCRs).1,4 1.Harrison, C., and Traynor, J.R.The [35S]GTPγS binding assay: Approaches and applications in pharmacologyLife Sci.74(4)489-508(2003) 2.Ihara, K., Muraguchi, S., Kato, M., et al.Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogueJ. Biol. Chem.273(16)9656-9666(1998) 3.Lito, P., Solomon, M., Li, L.-S., et al.Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanismScience351(6273)604-608(2016) 4.Strange, P.G.Use of the GTPγS ([35S]GTPγS and Eu-GTPγS) binding assay for analysis of ligand potency and efficacy at G protein-coupled receptorsBr. J. Pharmacol.161(6)1238-1249(2010) |
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