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4-Hydroxymidazolam
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-Hydroxymidazolam图片
CAS NO:59468-85-8
包装:1mg
市场价:8820元

产品介绍
4-Hydroxymidazolam 是 Midazolam 的一种主要代谢产物。Midazolam 是一种有效的苯二氮卓类药物，具有促进精神安定的活性。
Cas No.59468-85-8
别名4-羟基咪达唑仑
分子式C18H13ClFN3O
分子量341.77
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with sedative activities.

Midazolam is metabolized to 1’- and 4-hydroxymidazolam by CYP3A4 and CYP3A5 and is further metabolized to glucuronide conjugates by UDP-glucuronosyltransferases (UGTs)[1].

[1]. Seo KA, et al. Metabolism of 1’- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7. Drug Metab Dispos. 2010 Nov;38(11):2007-13.