α-Thujone

立即咨询

α-Thujone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

546-80-5

包装与价格：

包装	价格(元)
50mg	电议
100mg	电议

产品介绍

α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，具有有效的抗肿瘤活性。α-Thujone 是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，α-Thujone 的 IC50 为 21 μM。α-Thujone 诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡 (apoptosis ) 和自噬 (autophagy)。α-Thujone 具有抗伤害，杀虫和驱虫活性，并且很容易穿透血脑屏障。

Cas No.	546-80-5
别名	α-侧柏酮
分子式	C₁₀H₁₆O
分子量	152.23
溶解度	DMSO : 100 mg/mL (656.90 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier[1][2][3]. [1]. Agus HH, et al. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe). FEMS Yeast Res. 2020 Apr 29. pii: foaa022. [2]. Pude?ek M, et al. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro. Fitoterapia. 2019 Apr;134:172-181. [3]. HÖld KM, et al. Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3826-31.