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TRPV4 agonist-1 free base
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TRPV4 agonist-1 free base图片
CAS NO:2314467-59-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
TRPV4 agonist-1 free base 是一种瞬时受体电位香草酸亚型 4 (TRPV4) 激动剂，在 hTRPV4 Ca2+ 实验中 EC50 为 60 nM。
Cas No.2314467-59-7
分子式C25H22F2N4O2
分子量448.46
溶解度DMSO : 83.33 mg/mL (185.81 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1].

[1]. Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.