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1-(3-Chlorophenyl)biguanide(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-(3-Chlorophenyl)biguanide(hydrochloride)图片
CAS NO:2113-05-5
包装与价格:
包装价格(元)
1 g电议
5 g电议
10 g电议
25 g电议

产品介绍
A 5-HT3receptor agonist
Cas No.2113-05-5
Canonical SMILESClC1=CC=CC(NC(NC(N)=N)=N)=C1.Cl
分子式C8H10ClN5·HCl
分子量248.1
溶解度DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-(3-Chlorophenyl)biguanide (m-CPBG) is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.1It selectively binds 5-HT3over 5-HT1Aand 5-HT2receptors (Kis = 0.002, 10, and 10 µM, respectively) but also binds to high and low affinity sites on the dopamine transporter (DAT; IC50s = 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).2,3m-CPBG induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 µM, respectively).1,4It induces bradycardia, an effect that can be reversed by the 5-HT3receptor antagonist ondansetron, in anaesthetized cats (ED50= 20.3 nmol/kg).1

1.Kilpatrick, G.J., Butler, A., Burridge, J., et al.1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonistEur. J. Pharmacol.182(1)193-197(1990) 2.Campbell, A.D., Womer, D.E., and Simon, J.R.The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomesEur. J. Pharmacol.290(2)157-162(1995) 3.Higgins, G.A., Joharchi, N., and Sellers, E.M.Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in ratsJ. Pharmacol. Exp. Ther.264(3)1440-1449(1993) 4.Edwards, E., Hampton, E., Ashby, C.R., et al.5-HT3-like receptors in the rat medial prefrontal cortex: Further pharmacological characterizationBrain Res.733(1)21-30(1996)