| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 别名 | MDL-73147-d4 |
| Canonical SMILES | O=C(C1=CNC2=C([2H])C([2H])=C([2H])C([2H])=C12)O[C@@H]3C[C@@]4([H])[N@](CC5=O)[C@](C3)([H])CC5C4 |
| 分子式 | C19H16D4N2O3 |
| 分子量 | 328.4 |
| 溶解度 | Acetone: soluble,Acetonitrile: soluble,DMSO: soluble,Methanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dolasetron-d4is intended for use as an internal standard for the quantification of dolasetron by GC- or LC-MS. Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3(Ki= 20 nM).1It is selective for 5-HT3receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, and β-adrenergic, M1-5muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 µM for all).2Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50= 3.8 nM).1It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg.2Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea. 1.Beoijinga, P.H., Galvan, M., Baron, B.M., et al.Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cellsEur. J. Pharmacol.219(1)9-13(1992) 2.Miller, R.C., Galvan, M., Gittos, M.W., et al.Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptorsDrug Develop. Res.28(1)87-93(1993) |
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