您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Angiotensin III(human,mouse)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Angiotensin III(human,mouse)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiotensin III(human,mouse)图片
CAS NO:13602-53-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Angiotensin III (human, mouse) 是一种七肽,作为内源性血管紧张素 2 型受体 (AT2R) 激动剂,对 AT2R 和 AT1R 的 IC50 分别为 0.648 nM 和 21.1 nM。
Cas No.13602-53-4
别名血管紧张素III,Arg-Val-Tyr-Ile-His-Pro-Phe
化学名Angiotensin III (human, mouse)
Canonical SMILESCCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
分子式C46H66N12O9
分子量931.09
溶解度≥ 93.1mg/mL in DMSO
储存条件Desiccate at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Angiotensin III (Asp | Arg-Val-Tyr-Ile-His-Pro-Phe) is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II, a key factor in the Renin-Angiotensin-Aldosterone (RAAS) system by angiotensinases located in red blood cells and the vascular beds of most tissues. It has 40% of the presser activity of angiotensin II, but 100% of the aldosterone-producing activity.

In peripheral Ang systems, Ang II is the main effector peptide in the systemic circulation, although exogenous Ang III can be as potent as Ang II in, for example, stimulating aldosterone secretion [1] or inhibiting renin release [2]. In the rat brain, Ang III was found to be equipotent with Ang II as a pressor agent or dipsogen [3] and was bound as avidly to the nervous system as Ang II. Ang receptor subtype AT1 has greater affinity towards Ang II and is also responsive to Ang III, while the AT2 receptor subtype appears to be more sensitive to Ang III but less responsive to Ang II [4].

References:
1. Blair-West, JR. et al. (1980) J. Endocrinol. 87, 409.
2. Fei, DTW. et al. (1980) Life Sci. 27, 1495.
3. Fink, GD. et al. (1985) Am. J. Physiol. Endocrinol. Metab. 249, E201.
4. Wright, JW. et al. (2011) Prog. Neurobiol. 95, 49.