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N-Succinimidyl 3-(Bromoacetamido)propionate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Succinimidyl 3-(Bromoacetamido)propionate图片
CAS NO:57159-62-3
包装与价格:
包装价格(元)
50mg电议
100mg电议
1g电议

产品介绍
N-Succinimidyl 3-(Bromoacetamido)propionate 是一种 PROTAC linker,属于 PEG 类。可用于合成PROTAC分子。N-Succinimidyl 3-(Bromoacetamido)propionate 也是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。
Cas No.57159-62-3
别名3-(2-Bromoacetamido)propanoic acid NHS ester
分子式C9H11BrN2O5
分子量307.1
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.