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NH-bis-PEG2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NH-bis-PEG2图片
CAS NO:54384-47-3
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍
NH-bis-PEG2 是一种不可裂解 (non-cleavable) 的 2 单元 PEG 的 ADC linker,用于抗体药物偶联物 (ADCs) 的合成。NH-bis-PEG2 也是一种基于 PEG 的 PROTAC linker,可用于 PROTAC 的合成。
Cas No.54384-47-3
分子式C8H19NO4
分子量193.24
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NH-bis-PEG2 is a non-cleavable 2 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Brown A, et al. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750.