| 包装: | 20mg |
| 市场价: | 536元 |
Animal experiment: | Mice[3]1-year-old, male C57BL/6N mice (n=25) are randomized into four groups. Mice in the (-)-Epicatechin groups 3 and 4 are given 1.0 mg/kg twice a day (morning and evening) for 15 consecutive days, whereas animals in the control groups 1 and 2 receive the vehicle (water). Both (-)-Epicatechin and vehicle are administered via oral gavage[3]. |
| 产品描述 | (-)-Epicatechin is a flavonoid that increases NO levels and an inducer of pancreatic β-cell regeneration [1] [2]. β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin. (-)-Epicatechin is an inducer of pancreatic β-cell regeneration. In murine macrophages, (-)-Epicatechin induced nitrite accumulation induced by interferon-γ/lipopolysaccharide with IC50 value of 0.5 mM. Also, (-)-Epicatechin inhibited nitration of free tyrosine induced by 0.1 and 1 mM peroxynitrite with IC50 values of 6.6 and 28.0 μM, respectively. In HL-60 cells, (-)-Epicatechin inhibited nitration of protein-bound tyrosine induced by phorbol 12-myristate 13-acetate with IC50 value of 10-100 μM [2]. In human endothelial cells (HUVEC), (-)-Epicatechin (0.3-10 μM) increased NO levels, suggesting its vasodilatory properties [3]. In alloxan diabetic rats, (-)-Epicatechin (30 mg/kg) lowered blood sugar and restored the amount of beta-cells against alloxan-induced necrosis of the beta-cell population in the pancreatic islets. In rats, (-)-Epicatechin was non-toxic up to 1 g/kg [1]. In rats, oral administration of (-)-Epicatechin metabolized to 3’-O-methyl-(-)-epicatechin and 4’-O-methyl-(-)-epicatechin [4]. References: |
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