3',4',7-Trihydroxyisoflavone 是黄豆苷元的主要代谢物，是 Cot (Tpl2/MAP3K8) 和 MKK4 的 ATP 竞争性抑制剂。 3',4',7-三羟基异黄酮具有抗癌、抗血管生成、化学保护和自由基清除活性。
| Cas No. | 485-63-2 |
| 别名 | 3',4',7-三羟基异黄酮 |
| Canonical SMILES | OC1=CC=C(C(C(C2=CC(O)=C(O)C=C2)=CO3)=O)C3=C1 |
| 分子式 | C15H10O5 |
| 分子量 | 270.2 |
| 溶解度 | DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.1 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 3',4',7-Trihydroxyisoflavone is a natural isoflavonoid that has antioxidant activity. It can be produced by the metabolism of daidzein or daidzin . 3',4',7-Trihydroxyisoflavone inhibits several signaling pathways in cells, including tyrosinase-mediated melanin formation (IC50 = 5.2 µM), casein kinase II-mediated phosphorylation of 60S acidic ribosomal P proteins, and cyclin-dependent, kinase-regulated cell proliferation. |
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