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BAY-298
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BAY-298图片
CAS NO:2471978-97-7
包装:5mg
市场价:9450元

产品介绍
BAY-298 是一种口服有效和选择性的促黄体生成激素受体 (LH-R) 拮抗剂，对 hLH (人 LH)，rLH (大鼠 LH)和 cLH (食蟹猴LH) 的 IC50 分别为 96 nM，23 nM 和 78 nM。BAY-298 可以降低性激素水平。
Cas No.2471978-97-7
分子式C27H21ClFN3O2
分子量473.93
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels[1].

BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus[1]. BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po[1].

[1]. Wortmann L, et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. J Med Chem. 2019 Oct 31.