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Leukotriene B4-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Leukotriene B4-d5图片
包装与价格:
包装价格(元)
10 µg电议
25 µg电议

产品介绍
An internal standard for the quantification of LTB4
Canonical SMILESO[C@H](C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
分子式C20H27D5O4
分子量341.5
溶解度DMF: 50mg/mL,DMSO: 50mg/mL,Ethanol: 50mg/mL,PBS (pH 7.2): 1mg/mL
储存条件-80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leukotriene B4-d5(LTB4-d5) is intended for use as an internal standard for the quantification of LTB4by GC- or LC-MS. LTB4is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase (5-LO) pathway.1,2,3It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10-10 M), LTB4induces chemotaxis and chemokinesis in human polymorphonuclear leukocytes.4At higher concentrations, (1.0 x 10-7 M), LTB4leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5

1.RÅdmark, O., Malmsten, C., Samuelsson, B., et al.Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene BBiochem. Biophys. Res. Commun.92(3)954-961(1980) 2.Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al.Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytesNature286(5770)264-265(1980) 3.McGee, J., and Fitzpatrick, F.Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytesJ. Biol. Chem.260(23)12832-12837(1985) 4.Ford-Hutchinson, A.W.Leukotriene B4 in inflammationCrit. Rev. Immunol.10(1)1-12(1990) 5.McMillan, R.M., and Foster, S.J.Leukotriene B4 and inflammatory diseaseAgents Actions24(1-2)114-119(1988)