| 包装 | 价格(元) |
| 10 µg | 电议 |
| 25 µg | 电议 |
| Canonical SMILES | O[C@H](C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O |
| 分子式 | C20H27D5O4 |
| 分子量 | 341.5 |
| 溶解度 | DMF: 50mg/mL,DMSO: 50mg/mL,Ethanol: 50mg/mL,PBS (pH 7.2): 1mg/mL |
| 储存条件 | -80°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Leukotriene B4-d5(LTB4-d5) is intended for use as an internal standard for the quantification of LTB4by GC- or LC-MS. LTB4is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase (5-LO) pathway.1,2,3It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10-10 M), LTB4induces chemotaxis and chemokinesis in human polymorphonuclear leukocytes.4At higher concentrations, (1.0 x 10-7 M), LTB4leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5 1.RÅdmark, O., Malmsten, C., Samuelsson, B., et al.Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene BBiochem. Biophys. Res. Commun.92(3)954-961(1980) 2.Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al.Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytesNature286(5770)264-265(1980) 3.McGee, J., and Fitzpatrick, F.Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytesJ. Biol. Chem.260(23)12832-12837(1985) 4.Ford-Hutchinson, A.W.Leukotriene B4 in inflammationCrit. Rev. Immunol.10(1)1-12(1990) 5.McMillan, R.M., and Foster, S.J.Leukotriene B4 and inflammatory diseaseAgents Actions24(1-2)114-119(1988) |
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