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HIV-1 integrase inhibitor 8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HIV-1 integrase inhibitor 8图片
CAS NO:1568-80-5
包装与价格:
包装价格(元)
50mg电议
100mg电议

产品介绍
HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂,化合物 8。
Cas No.1568-80-5
别名3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇
分子式C21H24O2
分子量308.41
溶解度DMSO : 125 mg/mL (405.30 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].

HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1].The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1].

[1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3’, 3’-tetramethyl-1,1’-spirobi(indan)-5,5’,6,6’-tetrol Family.J Med Chem