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CDK7-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDK7-IN-3图片
CAS NO:2417302-07-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
CDK7-IN-3 (CDK7-IN-3) 是一种具有口服活性的高选择性非共价 CDK7 抑制剂,KD 为 0.065 nM。 CDK7-IN-3 对 CDK2 (Ki=2600 nM)、CDK9 (Ki=960 nM)、CDK12 (Ki=870 nM) 显示出较差的抑制作用。 CDK7-IN-3 诱导肿瘤细胞凋亡并具有抗肿瘤活性。
Cas No.2417302-07-7
别名7-(二甲基膦基)-3-[2-[[(3S)-6,6-二甲基-3-哌啶基]氨基]-5-(三氟甲基)-4-嘧啶基]-1H-吲哚-6-甲腈,CDK7-IN-3
分子式C23H26F3N6OP
分子量490.46
溶解度DMSO : 40 mg/mL (81.56 mM; Need ultrasonic)
储存条件4°C, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CDK7-IN-3 is a selective CDK7 inhibitor with a KD of 0.059 nM. CDK7-IN-3 shows poor inhibition on CDK2 (Ki=390 nM), CDK9 (Ki=290 nM), CDK12 (Ki=78 nM). CDK7-IN-3 induce apoptosis in tumor cells and has antitumor activity[1].

CDK7-IN-3 (compound 102; 126.4 pM-4 µM; 72 h) has an EC50 of 2.1 nM in HCC70 cell line[1].

[1]. Michael Bradley, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2020093011A1.