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IL-4 Inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IL-4 Inhibitor图片
CAS NO:1332184-63-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
IL-4 Inhibitor (compound 52) 是一种 IL-4 抑制剂,EC50 为 1.81 μM.
Cas No.1332184-63-0
Canonical SMILESN#CC1=C(N)N=C(C2=CC=C(F)C=C2)C=C1C3=CC(O)=C(O)C=C3
分子式C18H12FN3O2
分子量321.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

1.Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)