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CAY10753
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAY10753图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A TNKS2 inhibitor
Canonical SMILESO=C1NC(SCCN2CCN(CCSC(N3)=NC4=C(C=CC=C4)C3=O)CC2)=NC5=C1C=CC=C5
分子式C24H26N6O2S2
分子量494.6
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CAY10753 is an inhibitor of tankyrase 2 (TNKS2; IC50= 0.3 nM).1It is selective for TNKS2 over TNKS1 (IC50= 6.1 nM), as well as poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 89.6 and 37.8 nM, respectively). CAY10753 inhibits proliferation of DLD-1 colorectal cancer cells when used at a concentration of 1 µM.

1.Tomassi, S., Pfahler, J., Mautone, N., et al.From PARP1 to TNKS2 inhibition: A structure-based approachMed. Chem. Lett.(2020)