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PROTAC BRD4 Degrader-5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PROTAC BRD4 Degrader-5图片
CAS NO:2409538-70-9
包装:10mg
市场价:11700元

产品介绍
PROTACBRD4Degrader-5是一种基于PROTAC的BRD4降解剂,可有效降解HER2阳性和阴性乳腺癌细胞系中的BRD4。
Cas No.2409538-70-9
Canonical SMILESO=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
分子式C50H62ClN9O8S2
分子量1016.67
溶解度DMSO: 145 mg/mL (142.62 mM); Water:< 0.1 mg/mL (insoluble)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1]. Western Blot Analysis[1] Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells

[1]. Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.