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BI 9321
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BI 9321图片
包装:5mg
市场价:3043元

产品介绍
Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
Canonical SMILESCN1C=NC(C2=C(C=C(C=C2C)CN)C)=C1C3=C4C=CC(F)=CC4=NC=C3.Cl.Cl.Cl
分子式C22H21FN4.3HCl
分子量469.81
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

Böttcher et al (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 15 822 PMID:31285596