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TAT-cyclo-CLLFVY
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1446322-66-2
包装:1mg
市场价:1890元

产品介绍
TAT-cyclo-CLLFVY 是 HIF-1 异二聚化的环肽抑制剂,可抑制癌细胞中的缺氧信号传导。 TAT-cyclo-CLLFVY 破坏 HIF-1α/HIF-1β 蛋白质-蛋白质相互作用,IC50 为 1.3 μM。
Cas No.1446322-66-2
分子式C111H188N42O24S2
分子量2559.1
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID:23796364